CLINICAL MASS SPECTROMETRY GROUP
Clinical mass spectrometry, metabolomics and lipidomics for translational laboratory medicine
We develop and apply LC-MS/MS, metabolomics and lipidomics workflows to understand disease mechanisms, discover clinically relevant biomarkers and support the translation of omics technologies into laboratory medicine. We bridge the gap between academia and day-to-day clinical practice.
News
Join our new course on advanced technologies in lipidomics in Dresden, May 24–28, 2027
Ligasová A, et al. A hybrid RNA-based reporter assay for robust quantification of cytidine deaminase activity. (2026) Nucleic Acids Res. 54
Kadláčková M, et al. Derivatisation-free FIA-MS/MS assay for rapid simultaneous screening of atypical myopathy biomarkers and acylcarnitine profiles from dried blood spots. (2026) Anal Bioanal Chem.
Ďurišová I, et al. Long-Term Static Cultivation Alters Lipid Metabolism and Bioenergetic Capacity in A549 Cells. (2026) Int J Mol Sci. 27.
WHAT WE DO
Mass spectrometry workflows for clinically meaningful omics research
We combine clinical laboratory expertise with targeted mass spectrometry, metabolomics and lipidomics to study disease mechanisms and develop clinically meaningful analytical workflows.
Clinical LC-MS/MS
Development and validation of targeted LC-MS/MS methods for laboratory medicine, including small molecules, steroids, organic acids and biomarkers of inherited metabolic disorders.
Metabolomics
Targeted metabolomic workflows for the investigation of human disease, biochemical phenotyping and translational biomarker discovery.
Lipidomics
Quantitative lipidomics focused on inflammation, infection, cardiovascular risk and disease-associated remodeling of lipid pathways.
Multi-omics & data analysis
Integration of metabolomics, lipidomics, proteomics and clinical data using robust statistics, visualization and biomarker modelling.
CLINICAL QUESTIONS
Where we apply omics technologies
We apply mass spectrometry-based omics to clinically relevant questions where lipid and metabolite profiles may improve disease understanding, patient stratification or laboratory diagnostics.
Inflammation and infection
Distinguishing infectious and sterile inflammation using lipid and metabolite signatures in clinically relevant matrices.
Inherited metabolic disorders
LC-MS/MS workflows for selective screening, diagnostics and biochemical characterization of inborn errors of metabolism.
Cardiovascular risk lipidomics
Lipid-based risk stratification with a focus on ceramides, phospholipids and disease-associated lipid remodeling.
Immune-mediated diseases
Multi-omics profiling of inflammatory bowel disease and immune-mediated conditions using metabolomics, lipidomics and proteomics.
Perioperative and stress metabolism
Metabolic and lipidomic changes associated with surgery, stress response and clinical recovery.