Clinical metabolomics and lipidomics in human diseases
(Featured review: Clinical lipidomics in the era of the big data; https://doi.org/10.1515/cclm-2022-1105)
Tauopathy and neurodegenerative diseases
Metabolomic/lipidomic study of transgenic rat and mouse models of tauopathies, Alzheimer’s disease and Huntington’s disease
Dr. Andrej Kovac, Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia
Prof. Jens Pahnke, Section of Neuropathology Research, Department of Pathology (PAT), Rikshospitalet, Oslo, Norway
Effect of cytidine metabolic pathways on the therapy of hematological malignancies with cytarabine
New diagnostic tools for their analysis
Dr. Karel Koberna, Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University
(Featured grant: The impact of cytidine metabolic pathways on cytarabine therapy of hematological malignancies and new diagnostic tools for their analysis https://starfos.tacr.cz/en/projekty/NU22-08-00148)
Lung cancer
Metabolomic and lipidomic study of tissue samples from patients
Prof. Michal Holčapek, Department of Analytical Chemistry Pardubice, Faculty of Chemical Technology, University of Pardubice, Czechia
(Featured article: Lipidomic and metabolomic analysis reveals changes in biochemical pathways for non-small cell lung cancer tissues; Cífková E, Brumarová R, … https://doi.org/10.1016/j.bbalip.2021.159082)
Kidney cancer
Metabolomic and lipidomic study of plasma samples from patients
Prof. Michal Holčapek, Department of Analytical Chemistry Pardubice, Faculty of Chemical Technology, University of Pardubice, Czechia
Ing. Robert Jirásko, Ph.D., Department of Analytical Chemistry Pardubice, Faculty of Chemical Technology, University of Pardubice, Czechia
Ing. Jakub Idkowiak, Department of Analytical Chemistry Pardubice, Faculty of Chemical Technology, University of Pardubice, Czechia
(Featured article: Altered plasma, urine, and tissue profiles of sulfatides and sphingomyelins in patients with renal cell carcinoma; Jirásko R, Idkowiak J, … https://doi.org/10.3390/cancers14194622)
Sweat as clinically useful biofluid
Metabolomic and lipidomic analysis of non-invasively acquired apocrine sweat
Prof. Zdeněk Zadák, M.D. University Hospital Hradec Králové, Czechia
(Featured article: SLIDE—Novel Approach to Apocrine Sweat Sampling for Lipid Profiling in Healthy Individuals; Kvasnička A, Friedecký D, … https://doi.org/10.3390/ijms22158054)
Untargeted metabolomics
Discovery and characterization of new biomarkers, elucidation of structures of unknown molecules
Lukáš Najdekr, Ph.D., Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University
Development of advanced statistical tools
Prof. Karel Hron, Department of Statistical analysis, Faculty of Science, Palacky University Olomouc, Czechia
Glutamate carboxypeptidase II (GCPII)
Metabolomic/lipidomic study of transgenic mice models
MUDr. František Sedlák, Ph.D., Charles University of Prague, Czechia
Prof. Jan Konvalinka, Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Czechia
Lipidomic analysis of synovial fluid
The use of lipidomic analysis in the characterization of selected pathologies of the joint system
Assoc. Prof. Eva Kriegová, Department of Immunology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc
Hyperuricemia
Lipidomic profiling of plasma from patients with gout and hyperuricemia
Assoc. Prof. Blanka Stibůrková, Institute of Rheumatology, Department of Pediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital in Prague
Eicosanoids as therapeutic targets in cardiology
Lipidomic profiling of plasma from patients with heart failure
Assoc. Prof. Karel Kotaška, Department of Medical Chemistry and Clinical Biochemistry, Second Faculty of Medicine, University Hospital Motol, Charles University
Advanced analytical tools for diagnosing inborn errors of metabolism
Development of multicomponent LC/MS methods
Laboratory for Inherited Metabolic Disorders, University Hospital Olomouc, Czechia
(Featured review: Novel LC-MS tools for diagnosing inborn errors of metabolism; Ivanovová E, Piskláková B, … https://doi.org/10.1016/j.microc.2021.106654)
(Featured article: Rapid and efficient LC-MS/MS diagnosis of inherited metabolic disorders: a semi-automated workflow for analysis of organic acids, acylglycines, and acylcarnitines in urine; Piskláková B, Friedecká J, … https://doi.org/10.1515/cclm-2023-0084)
(Featured grant: New biomarkers of inherited metabolic diseases; https://starfos.tacr.cz/en/projekty/NU20-08-00367?query=6ofyaac64k7q)
Short-chain acyl-CoA dehydrogenase deficiency (SCADD) and transmembrane protein 70 deficiency (TMEM70)
Metabolomic and lipidomic study of dry blood spots from newborn patients
Prof. Michael Lämmerhofer, Institute of Pharmaceutical Sciences, Pharmaceutical (Bio-)Analysis, University of Tübingen, Germany
Dr. Maria Knapkova, Children’s University Hospital, Banská Bystrica, Slovakia
Clinical metabolomics in animal diseases
Atypical myopathy
Metabolite profiling of serum, DBS and urine from horses
MVDr. Petr Jahn, CSc., Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences, Brno, Czechia
(Featured article: Dynamics of acylcarnitines, hypoglycin A, méthylènecyclopropylglycine and their metabolites in a Kladruber stallion with atypical myopathy; Jahn P, Dobešová D, Brumarová R, … https://doi.org/10.1080/01652176.2022.2126537)