2024
#9 Long-chain polyunsaturated fatty acid-containing phosphatidylcholines predict survival rate in patients after heart failure; Kvasnička A, Kotaška K, Friedecký D, Ježdíková K, Brumarová R, Hnát T, Kala P, Heliyon, 2024, Vol. 10, Issue 21, p. e39979, https://doi.org/10.1016/j.heliyon.2024.e39979
#8 A global perspective on the status of clinical metabolomics in laboratory medicine – a survey by the IFCC metabolomics working group; Fux E, Lenski M, Bendt AK, Otvos JD, Ivanisevic J, De Bruyne S, Cavalier E, Friedecký D, Clinical Chemistry and Laboratory Medicine, 2024,Vol. 62, Issue 10, pp. 1950–1961, https://doi.org/10.1515/cclm-2024-0550
#7 Changes in lipid metabolism track with the progression of neurofibrillary pathology in tauopathies; Olešová D, Dobešová D, Majerová P, Brumarová R, Kvasnička A, Kouřil Š, Stevens E, Hanes J, Fialová Ľ, Michalicová A, Piešťanský J, Šinský J, Kaňovský P, Friedecký D, Kováč A, Journal of Neuroinflammation, 2024, Vol. 21, Issue 78, https://doi.org/10.1186/s12974-024-03060-4
#6 Assessing HCH isomer uptake in Alnus glutinosa: implications for phytoremediation and microbial response; Amirbekov A, Vrchovecka S, Riha J, Petrik I, Friedecky D, Novak O, Cernik M, Hrabak P, Sevcu A, Scientific Reports, 2024, Vol. 14, Issue 1, https://doi.org/10.1038/s41598-024-54235-1
#5 Parallel Metabolomics and Lipidomics of a PSMA/GCPII Deficient Mouse Model Reveal Alteration of NAAG Levels and Brain Lipid Composition; Sedlák F, Kvasnička A, Marešová B, Brumarová R, Dobešová D, Dostálová K, Šrámková K, Pehr M, Šácha P, Friedecký D, Konvalinka J, ACS Chemical Neuroscience, 2024, Vol. 15, Issue 7, pp. 1342–1355, https://doi.org/10.1021/acschemneuro.3c00494
#4 Wide metabolite coverage LC-MS/MS assay for the diagnosis of inherited metabolic disorders in urine; Ivanovová E, Piskláková B, Dobešová D, Janečková H, Foltenová H, Kvasnička A, Prídavok M, Bouchalová K, de Sousa J, Friedecký D, Talanta, 2024, Vol. 271, p. 125699, https://doi.org/10.1016/j.talanta.2024.125699
#3 Patients with Neurodegenerative Proteinopathies Exhibit Altered Tryptophan Metabolism in the Serum and Cerebrospinal Fluid; Kaleta M, Hényková E, Menšíková K, Friedecký D, Kvasnička A, Klíčová K, Koníčková D, Strnad M, Kaňovský P, Novák O, ACS Chemical Neuroscience, 2024, Vol. 15, Issue 3, p. 582–592 https://doi.org/10.1021/acschemneuro.3c00611
#2 Utilizing neurodegenerative markers for the diagnostic evaluation of amyotrophic lateral sclerosis, Klíčová K, Mareš J, Menšíková K, Kaiserová M, Friedecký D, Kaňovský P, Strnad M, Matěj R, European Journal of Medical Research, 2024, Vol. 29, Issue 1, https://doi.org/10.1186/s40001-023-01596-4
#1 Aminoacylase 1 deficiency: case report on three affected siblings; Smolka V, Friedecky D, Kolarova J, Tkacik O, Foltenova H, Bekarek V, Vrtel P, Srovnal J. Aminoacylase 1 deficiency: case report on three affected siblings, AME Case Rep, 2023, Vol. 8, pp. 18–18, https://doi.org/10.21037/acr-23-46
2023
#11 Determining Thrombogenicity: Using a Modified Thrombin Generation Assay to Detect the Level of Thrombotic Event Risk in Lupus Anticoagulant-Positive Patients; Bradáčová P, Slavík L, Úlehlová J, Kriegová E, Jará E, Bultasová L, Friedecký D, Ullrychová J, Procházková J, Hluší A, Manukyan G, Lenka Štefaničková L, Biomedicines. 2023; 11(12):3329. https://doi.org/10.3390/biomedicines11123329
#10 Alterations in lipidome profiles distinguish early-onset hyperuricemia, gout, and the effect of urate-lowering treatment; Kvasnička A, Friedecký D, Brumarová R, Pavlíková M, Pavelcová K, Mašínová J, Hasíková L, Závada J, Pavelka K, Ješina P, Stibůrková B, Arthritis Research & Therapy, 2023, (Vol. 25, Issue 1), https://doi.org/10.1186/s13075-023-03204-6
#9 A new technique for the analysis of metabolic pathways of cytidine analogues and cytidine deaminase activities in cells; Ligasová A, Piskláková B, Friedecký D, Koberna K, Scientific Reports, 2023, 20530, https://doi.org/10.1038/s41598-023-47792-4
#8 Multivariate Independent Component Analysis Identifies Patients in Newborn Screening Equally to Adjusted Reference Ranges; Kouřil Š, de Sousa J, Fačevicová K, Gardlo A, Muehlmann C, Nordhausen K, Friedecký D, Adam T, International Journal of Neonatal Screening, 2023, 9 (4), https://doi.org/10.3390/ijns9040060
#7 Principal balances of compositional data for regression and classification using partial least squares; Nesrstová V, Wilms I, Palarea-Albaladejo J, Filzmoser P, Martín-Fernández J A, Friedecký D, Hron K, Journal of Chemometrics. 2023;e3518. https://doi.org/10.1002/cem.3518
#6 Cerebrospinal fluid and blood serum biomarkers in neurodegenerative proteinopathies: A prospective, open, cross-correlation study; Koníčková D, Menšíková K, Klíčová K, Chudáčková M, Kaiserová M, Přikrylová H, Otruba P, Nevrlý M, Hluštík P, Hényková E, Kaleta M, Friedecký D, Matěj R, Strnad M, Novák O, Plíhalová L, Rosales R, Colosimo C, Kaňovský P, Journal of Neurochemistry, 2023, 00, 1–15. https://doi.org/10.1111/jnc.15944
#5 The importance of ceramide assay in the primary prevention of cardiovascular disease; Kvasnička A, Kouřil Š, Brumarová R, Piskláková B, Štefaničková L, Friedecký D, Klinická Biochemie a Metaboismus, 31 (52), 2023, No. 2, p. 32 – 36. https://casopiskbm.cz/wp-content/uploads/KBM/22023/obsah_223/KBM_2_2023_2.pdf
#4 Systematic Comparison of Advanced Network Analysis and Visualization of Lipidomics; Schwarzerová J, Olešová D, Kvasnička A, Friedecký D, Varga M, Provazník V, Wolfram Weckwerth W, Bioinformatics and Biomedical Engineering. IWBBIO 2023. Lecture Notes in Computer Science, vol 13919. Springer, Cham. https://doi.org/10.1007/978-3-031-34953-9_30
#3 Selective pivot logratio coordinates for PLS-DA modelling with applications in metabolomics; de Sousa J, Štefelová N, Hron K, Palarea-Albaladejo J, Dobešová D, Kvasnička A, Friedecký D, Stat, 2023, https://doi.org/10.1002/sta4.592
#2 Rapid and efficient LC-MS/MS diagnosis of inherited metabolic disorders: a semi-automated workflow for analysis of organic acids, acylglycines, and acylcarnitines in urine; Piskláková B, Friedecká J, Ivanovová E, Hlídková E, Bekárek V, Prídavok M, Kvasnička A, Adam T, Friedecký D, Clinical Chemistry and Laboratory Medicine (CCLM), 2023, 61(11), https://doi.org/10.1515/cclm-2023-0084
#1 Clinical lipidomics in the era of the big data; Kvasnička A, Najdekr L, Dobešová D, Piskláková B, Ivanovová E, Friedecký D, Clinical Chemistry and Laboratory Medicine (CCLM), 2022, 61(4), https://doi.org/10.1515/cclm-2022-1105
2022
#10 From big data to better patient outcomes; Hulsen T, Friedecký D, Renz H, Melis E, Vermeersch P, Fernandez-Calle P, Clinical Chemistry and Laboratory Medicine (CCLM), 2022, 61(4), https://doi.org/10.1515/cclm-2022-1096
#9 Altered plasma, urine, and tissue profiles of sulfatides and sphingomyelins in patients with renal cell carcinoma; Jirásko R, Idkowiak J, Wolrab D, Kvasnička A, Friedecký D, Polański K, Študentová H, Študent V, Melichar B, Holčapek M, Cancers, 2022, 14(19), 4622; https://doi.org/10.3390/cancers14194622
#8 Dynamics of acylcarnitines, hypoglycin A, méthylènecyclopropylglycine and their metabolites in a Kladruber stallion with atypical myopathy; Jahn P, Dobešová D, Brumarová R, Tóthová K, Kopecká A, Friedecký D, Veterinary Quarterly, 2022; (pp. 1–12) https://doi.org/10.1080/01652176.2022.2126537
#7 Specific gut bacterial and fungal microbiota pattern in the first half of pregnancy is linked to the development of gestational diabetes mellitus in the cohort including obese women; Vavreckova M, Galanova N, Kostovcik M, Krystynik O, Ivanovova E, Roubalova R, Jiraskova Zakostelska Z, Friedecky D, Friedecka J, Haluzik M, Karasek D, Kostovcikova K, Frontiers in Endocrinology (section Clinical Diabetes), 2022, (13:970825) doi: 10.3389/fendo.2022.970825
#6 Determination of Thrombogenicity Levels of Various Antiphospholipid Antibodies by a Modified Thrombin Generation Assay in Patients with Suspected Antiphospholipid Syndrome; Bradáčová P, Slavík L, Skoumalová A, Úlehlová J, Kriegová E, Manukyan G, Friedecký D, Piskláková B, Ullrychová J, Procházková J, Hluší A. International Journal of Molecular Sciences. 2022; 23(16):8973. https://doi.org/10.3390/ijms23168973
#5 Biomarkers of Neurodegenerative Diseases: Biology, Taxonomy, Clinical Relevance, and Current Research Status; Koníčková D, Menšíková K, Tučková L, Hényková E, Strnad M, Friedecký D, Stejskal D, Matěj R, Kaňovský P, Biomedicines, 2022; 10(7):1760. https://doi.org/10.3390/biomedicines10071760
#4 Metabolomic, lipidomic and proteomic characterisation of lipopolysaccharide-induced inflammation mouse model; Puris E, Kouřil Š, Najdekr L, Auriola S, Loppi S, Korhonen P, Gómez-Budia M, Fricker G, Kanninen K M, Malm T, Friedecký D, Gynther M, Neuroscience, 2022, (Vol. 496, pp. 165–178), https://doi.org/10.1016/j.neuroscience.2022.05.030
#3 Combined Targeted and Untargeted Profiling of HeLa Cells Deficient in Purine De Novo Synthesis; Mádrová L, Součková O, Brumarová R, Dobešová D, Václavík J, Kouřil Š, de Sousa J, Friedecká J, Friedecký D, Barešová V, Zikánová M, Adam T, Metabolites. 2022 12, 241. https://doi.org/10.3390/metabo12030241
#2 Lipidomic profiling of human serum enables detection of pancreatic cancer; Wolrab D, Jirásko R, Cífková E, Höring M, Mei D, Chocholoušková M, Peterka O, Idkowiak J, Hrnčiarová T, Kuchař L, Ahrends R, Brumarová R, Friedecký D, Vivo-Truyols G, Škrha P, Škrha J, Kučera R, Melichar B, Liebisch G, Burkhardt R, Wenk M, Cazenave-Gassiot A, Karásek P, Novotný I, Greplová K, Hrstka R, Holčapek M, Nature Communications. 2022 13(1). https://doi.org/10.1038/s41467-021-27765-9
#1 Lipidomic and metabolomic analysis reveals changes in biochemical pathways for non-small cell lung cancer tissues; Cífková E, Brumarová R, Ovčačíková M, Dobešová D, Mičová K, Kvasnička A, Vaňková Z, Šiller J, Sákra L, Friedecký D, Holčapek M, Biochimica et Biophysica Acta (BBA) – Molecular and Cell Biology of Lipids. 2022 (Vol. 1867, Issue 2, p. 159082). Elsevier BV. https://doi.org/10.1016/j.bbalip.2021.159082
2021
#7 GM3 Ganglioside Linked to Neurofibrillary Pathology in a Transgenic Rat Model for Tauopathy; Olešová, D., Majerová, P., Hájek, R., Piešťanský, J., Brumarová, R., Michalicová, A., Jurkanin, B., Friedecký, D., Kováč, A. Int. J. Mol. Sci. 2021, 22, 12581. https://doi.org/10.3390/ijms222212581
#6 Evaluation of the Determination of Dabigatran, Rivaroxaban, and Apixaban in Lupus Anticoagulant-Positive Patients; Úlehlová J, Piskláková B, Ivanovová E, Procházková J, Bradáčová P, Kvasnička A, Friedecký D, Slavík L, Diagnostics. 2021; 11(11):2027. https://doi.org/10.3390/diagnostics11112027
#5 Plasma Short-Chain Fatty Acids and Their Derivatives in Women with Gestational Diabetes Mellitus; Ivanovová E, Piskláková B, Friedecká J, Krystyník O, Friedecký D, Karásek D. Separations. 2021; 8(10):188. https://doi.org/10.3390/separations8100188
#4 Impact of Newborn Screening and Early Dietary Management on Clinical Outcome of Patients with Long Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency and Medium Chain Acyl-CoA Dehydrogenase Deficiency—A Retrospective Nationwide Study; Rücklová K, Hrubá E, Pavlíková M, Hanák P, Farolfi M, Chrastina P, Vlášková H, Kousal B, Smolka V, Foltenová H, Adam T, Friedecký D, Ješina P, Zeman J, Kožich V, Honzík T, Nutrients. 2021; 13(9):2925. https://doi.org/10.3390/nu13092925
#3 SLIDE—Novel Approach to Apocrine Sweat Sampling for Lipid Profiling in Healthy Individuals; Kvasnička A, Friedecký D, Tichá A, Hyšpler R, Janečková H, Brumarová R, Najdekr L, Zadák Z, Int. J. Mol. Sci. 2021;22: 8054. https://doi.org/10.3390/ijms22158054
#2 Novel LC-MS tools for diagnosing inborn errors of metabolism; Ivanovová E, Piskláková B, Dobešová D, Kvasnička A, Friedecký D, Microchem J. 2021 Jul; 170, 106654. https://doi.org/10.1016/j.microc.2021.106654
#1 Metabolomic and lipidomic changes triggered by lipopolysaccharide-induced systemic inflammation in transgenic APdE9 mice; Puris E, Kouřil Š, Najdekr L, Loppi S, Korhonen P, Kanninen KM, Malm T, Koistinaho J, Friedecký D, Gynther M, Sci Rep. 2021 Jun 22;11(1):13076. https://doi.org/10.1038/s41598-021-92602-4
2020-1999
A newborn screening approach to diagnose 3-hydroxy-3-methylglutaryl-CoA lyase deficiency; Václavík J, Mádrová L, Kouřil Š, de Sousa J, Brumarová R, Janečková H, Jáčová J, Friedecký D, Knapková M, Kluijtmans LAJ, Grünert SC, Vaz FM, Janzen N, Wanders RJA, Wevers RA, Adam T.; JIMD Rep. 2020 Apr 14; 54(1):79-86. https://doi.org/10.1002/jmd2.12118 eCollection 2020 Jul.
Global DNA methylation in rats´ liver is not affected by hypercholesterolemic diet; Jurcikova-Novotna L, Mrazova L, Mičová K, Friedecký D, Hubacek JA, Poledne R.; Physiol Res. 2020 Apr 30; 69(2):347-252. https://doi.org/10.33549/physiolres.934313 Epub 2020 Mar 23.
Cellwise outlier detection and biomarker identification in metabolomics based on pairwise log ratios; Walach J, Filzmoser P, Kouřil Š, Friedecký D, Adam T.; J Chemom. 2020 Jan; 34(1):e3182. https://doi.org/10.1002/cem.3182 Epub 2019 Dec 2.
CROP: correlation-based reduction of feature multiplicities in untargeted metabolomic data; Kouřil Š, de Sousa J, Václavík J, Friedecký D, Adam T.; Bioinformatics. 2020 May 1; 36(9):2941-2942. https://doi.org/10.1093/bioinformatics/btaa012
Bayesian multiple hypotheses testing in compositional analysis of untargeted metabolomic data; de Sousa J, Vencálek O, Hron K, Václavík J, Friedecký D, Adam T.; Anal Chim Acta. 2020 Feb 8; 1097:49-61. doi: 10.1016/j.aca.2019.11.006. Epub 2019 Nov 16.
Evaluation of the DOAC-Stop Procedure by LC-MS/MS Assays for Determining the Residual Activity of Dabigatran, Rivaroxaban, and Apixaban; Slavik L, Jacova J, Friedecky D, Ulehlova J, Tauber Z, Prochazkova J, Hlusi A, Palova M.; Clin Appl Thromb Hemost. 2019 Jan-Dec; 25:1076029619872556. doi: 10.1177/1076029619872556.
Urease-immobilized magnetic microparticles in urine sample preparation for metabolomic analysis by gas chromatography-mass spectrometry; Jáčová J, Jořenek M, Pospíšková K, Najdekr L, Zajoncová L, Friedecký D, Adam T.; J Chromatogr A. 2019 Nov 8; 1605:360355. doi: 10.1016/j.chroma.2019.07.009. Epub 2019 Jul 10.
Epidemiology of rare diseases detected by newborn screening in the Czech Republic; David J, Chrastina P, Pešková K, Kožich V, Friedecký D, Adam T, Hlídková E, Vinohradská H, Novotná D, Hedelová M, Al Taji E, Holubová A, Skalická V, Macek M, Gaillyová R, Votava F.; Cent Eur J Public Health. 2019 Jun; 27(2):153-159. doi: 10.21101/cejph.a5441.
White Adipose Tissue Response of Obese Mice to Ambient Oxygen Restriction at Thermoneutrality: Response Markers Identified, but no WAT Inflammation; Hoevenaars FPM, Keijer J, van der Stelt I, Duivenvoorde LPM, Herreman L, van Nes R, Friedecký D, Hegeman MA, van Schothorst EM.; Genes (Basel). 2019 May 10; 10(5):359. doi: 10.3390/genes10050359.
Impact of sample dimensionality on orthogonality metrics in comprehensive two-dimensional separations; Jáčová J, Gardlo A, Dimandja JD, Adam T, Friedecký D.; Anal Chim Acta. 2019 Aug 8; 1064:138-149. doi: 10.1016/j.aca.2019.03.018. Epub 2019 Mar 12.
Mass spectrometric analysis of purine de novo biosynthesis intermediates; Mádrová L, Krijt M, Barešová V, Václavík J, Friedecký D, Dobešová D, Součková O, Škopová V, Adam T, Zikánová M.; PLoS One. 2018 Dec 10; 13(12):e0208947. doi: 10.1371/journal.pone.0208947. eCollection 2018.
Human White Adipose Tissue Metabolome: Current Perspective; Kučera J, Spáčil Z, Friedecký D, Novák J, Pekař M, Bienertová-Vašků J.; Obesity (Silver Spring). 2018 Dec; 26(12):1870-1878. doi: 10.1002/oby.22336. Epub 2018 Oct 28.
Multianalyte Determination of NOACs Using LC-MS/MS and Comparison with Functional Coagulation Assays; Slavik L, Lukes J, Friedecky D, Zhanelova M, Nemcova M, Ulehlova J, Prochazkova J, Hlusi A, Palova M, Vaclavik J.; Clin Lab. 2018 Oct 1; 64(10):1611-1621. doi: 10.7754/Clin.Lab.2018.180335.
Newborn foal with atypical myopathy; Karlíková R, Široká J, Mech M, Friedecký D, Janečková H, Mádrová L, Hrdinová F, Drábková Z, Dobešová O, Adam T, Jahn P.; J Vet Intern Med. 2018 Sep; 32(5):1768-1772. doi: 10.1111/jvim.15236. Epub 2018 Sep 14.
Radio-sensitizing effects of VE-821 and beyond: Distinct phosphoproteomic and metabolomic changes after ATR inhibition in irradiated MOLT-4 cells; Šalovská B, Janečková H, Fabrik I, Karlíková R, Čecháková L, Ondrej M, Link M, Friedecký D, Tichý A.; PLoS One. 2018 Jul 12; 13(7):e0199349. doi: 10.1371/journal.pone.0199349. eCollection 2018.
Structural elucidation of novel biomarkers of known metabolic disorders based on multistage fragmentation mass spectra; Václavík J, Coene KLM, Vrobel I, Najdekr L, Friedecký D, Karlíková R, Mádrová L, Petsalo A, Engelke UFH, van Wegberg A, Kluijtmans LAJ, Adam T, Wevers RA.; J Inherit Metab Dis. 2018 May; 41(3):407-414. doi: 10.1007/s10545-017-0109-4. Epub 2017 Nov 14.
Metabolic status of CSF distinguishes rats with tauopathy from controls; Karlíková R, Mičová K, Najdekr L, Gardlo A, Adam T, Majerová P, Friedecký D, Kováč A.; Alzheimers Res Ther. 2017 Sep 21; 9(1):78. doi: 10.1186/s13195-017-0303-5.
Toll-Like Receptor 7/8 Ligand, S28463, Suppresses Ascaris suum-induced Allergic Asthma in Nonhuman Primates; Camateros P, Kanagaratham C, Najdekr L, Holub D, Vrbkova J, Coté L, Fournier J, Gourdon J, Creery D, Olivenstein R, Kopriva F, Adam T, Friedecký D, Džubák P, Hajdúch M, Radzioch D.; Am J Respir Cell Mol Biol. 2018 Jan; 58(1):55-65. doi: 10.1165/rcmb.2017-0184OC.
Sample-independent approach to normalize two-dimensional data for orthogonality evaluation using whole separation space scaling; Jáčová J, Gardlo A, Friedecký D, Adam T, Dimandja JD.; J Chromatogr A. 2017 Aug 18; 1511:1-8. doi: 10.1016/j.chroma.2017.06.076. Epub 2017 Jul 3.
Novel sulphur-containing imatinib metabolites found by untargeted LC-HRMS analysis; Vrobel I, Friedecký D, Faber E, Najdekr L, Mičová K, Karlíková R, Adam T.; Eur J Pharm Sci. 2017 Jun 15; 104:335-343. doi: 10.1016/j.ejps.2017.04.014. Epub 2017 Apr 20.
Metabolic Response of Visceral White Adipose Tissue of Obese Mice Exposed for 5 Days to Human Room Temperature Compared to Mouse Thermoneutrality; van der Stelt I, Hoevenaars F, Široká J, de Ronde L, Friedecký D, Keijer J, van Schothorst E.; Front Physiol. 2017 Mar 23; 8:179. doi: 10.3389/fphys.2017.00179. eCollection 2017.
Influence of Mass Resolving Power in Orbital Ion-Trap Mass Spectrometry-Based Metabolomics; Najdekr L, Friedecký D, Tautenhahn R, Pluskal T, Wang J, Huang Y, Adam T.; Anal Chem. 2016 Dec 6; 88(23):11429-11435. doi: 10.1021/acs.analchem.6b02319. Epub 2016 Nov 23.
Equine atypical myopathy: A metabolic study; Karlíková R, Široká J, Jahn P, Friedecký D, Gardlo A, Janečková H, Hrdinová F, Drábková Z, Adam T.; Vet J. 2016 Oct; 216:125-32. doi: 10.1016/j.tvjl.2016.07.015. Epub 2016 Jul 29.
Metabolite Profiling of the Plasma and Leukocytes of Chronic Myeloid Leukemia Patients; Karlíková R, Široká J, Friedecký D, Faber E, Hrdá M, Mičová K, Fikarová I, Gardlo A, Janečková H, Vrobel I, Adam T.; J Proteome Res. 2016 Sep 2; 15(9):3158-66. doi: 10.1021/acs.jproteome.6b00356. Epub 2016 Aug 9.
Ultrafast Online SPE-MS/MS Method for Quantification of 3 Tyrosine Kinase Inhibitors in Human Plasma; Vrobel I, Janečková H, Faber E, Bouchalová K, Mičová K, Friedecký D, Adam T.; Ther Drug Monit. 2016 Aug; 38(4):516-24. doi: 10.1097/FTD.0000000000000309.
Dr Jekyll and Mr Hyde: a strange case of 5-ethynyl-2′-deoxyuridine and 5-ethynyl-2′-deoxycytidine; Ligasová A, Liboska R, Friedecký D, Mičová K, Adam T, Oždian T, Rosenberg I, Koberna K.; Open Biol. 2016 Jan; 6(1):150172. doi: 10.1098/rsob.150172.
Detailed study of imatinib metabolization using high-resolution mass spectrometry; Friedecký D, Mičová K, Faber E, Hrdá M, Široká J, Adam T.; J Chromatogr A. 2015 Aug 28; 1409:173-81. doi: 10.1016/j.chroma.2015.07.033. Epub 2015 Jul 13.
Citrulline as a biomarker of gastrointestinal toxicity in patients with rectal carcinoma treated with chemoradiation; Zezulová M, Bartoušková M, Hlídková E, Adam T, Kujovská Krčmová L, Červinková B, Solichová D, Zlevorová M, Cwiertka K, Friedecký D, Vrána D, Melichar B.; Clin Chem Lab Med. 2016 Feb; 54(2):305-14. doi: 10.1515/cclm-2015-0326.
A lower dosage of imatinib is sufficient to maintain undetectable disease in patients with chronic myeloid leukemia with long-term low-grade toxicity of the treatment; Faber E, Divoká M, Skoumalová I, Novák M, Marešová I, Mičová K, Friedecký D, Adam T, Jarošová M, Indrák K.; Leuk Lymphoma. 2016 Feb; 57(2):370-375. doi: 10.3109/10428194.2015.1056184. Epub 2015 Jun 22.
Oxidized phosphatidylcholines suggest oxidative stress in patients with medium-chain acyl-CoA dehydrogenase deficiency; Najdekr L, Gardlo A, Mádrová L, Friedecký D, Janečková H, Correa ES, Goodacre R, Adam T.; Talanta. 2015 Jul 1; 139:62-6. doi: 10.1016/j.talanta.2015.02.041. Epub 2015 Mar 4.
A fatal combination: a thymidylate synthase inhibitor with DNA damaging activity; Ligasová A, Strunin D, Friedecký D, Adam T, Koberna K.; PLoS One. 2015 Feb 11; 10(2):e0117459. doi: 10.1371/journal.pone.0117459. eCollection 2015.
Untargeted metabolomic analysis of urine samples in the diagnosis of some inherited metabolic disorders; Janeckova H, Kalivodova A, Najdekr L, Friedecky D, Hron K, Bruheim P, Adam T.; Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015 Dec; 159(4):582-5. doi: 10.5507/bp.2014.048. Epub 2014 Nov 7.
Fenretinide prevents inflammation and airway hyperresponsiveness in a mouse model of allergic asthma; Kanagaratham C, Kalivodová A, Najdekr L, Friedecký D, Adam T, Hajduch M, De Sanctis JB, Radzioch D.; Am J Respir Cell Mol Biol. 2014 Dec; 51(6):783-92. doi: 10.1165/rcmb.2014-0121OC.
Analysis of cytokinin nucleotides by capillary zone electrophoresis with diode array and mass spectrometric detection in a recombinant enzyme in vitro reaction; Béres T, Gemrotová M, Tarkowski P, Ganzera M, Maier V, Friedecký D, Dessoy MA, Wessjohann LA, Spíchal L, Strnad M, Doležal K.; Anal Chim Acta. 2012 Nov 2; 751:176-81. doi: 10.1016/j.aca.2012.08.049. Epub 2012 Sep 5.
A significant proportion of patients with chronic myeloid leukemia and suboptimal response according to European Leukemia Net criteria have excellent prognosis without treatment change; Rohon P, Faber E, Divoka M, Rozmanova S, Friedecky D, Jarosova M, Indrak K.; Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2013 Jun; 157(2):181-8. doi: 10.5507/bp.2011.059. Epub 2011 Nov 30.
High lapatinib plasma levels in breast cancer patients: risk or benefit?; Cizkova M, Bouchalova K, Friedecky D, Polynkova A, Janostakova A, Radova L, Cwiertka K, Trojanec R, Zezulova M, Zlevorova M, Hajduch M, Melichar B.; Tumori. 2012 Jan-Feb; 98(1):162-5. doi: 10.1700/1053.11516.
Isotope dilution direct injection mass spectrometry method for determination of four tyrosine kinase inhibitors in human plasma; Mičová K, Friedecký D, Faber E, Adam T.; Talanta. 2012 May 15; 93:307-13. doi: 10.1016/j.talanta.2012.02.038. Epub 2012 Feb 22.
Imatinib trough plasma levels do not correlate with the response to therapy in patients with chronic myeloid leukemia in routine clinical setting; Faber E, Friedecký D, Mičová K, Rožmanová S, Divoká M, Jarošová M, Indrák K, Adam T.; Ann Hematol. 2012 Jun; 91(6):923-9. doi: 10.1007/s00277-011-1394-x. Epub 2012 Jan 11.
Targeted metabolomic analysis of plasma samples for the diagnosis of inherited metabolic disorders; Janečková H, Hron K, Wojtowicz P, Hlídková E, Barešová A, Friedecký D, Zídková L, Hornik P, Behúlová D, Procházková D, Vinohradská H, Pešková K, Bruheim P, Smolka V, Sťastná S, Adam T.; J Chromatogr A. 2012 Feb 24; 1226:11-7. doi: 10.1016/j.chroma.2011.09.074. Epub 2011 Oct 4.
Lapatinib in breast cancer – the predictive significance of HER1 (EGFR), HER2, PTEN and PIK3CA genes and lapatinib plasma level assessment; Bouchalova K, Cizkova M, Cwiertka K, Trojanec R, Friedecky D, Hajduch M.; Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2010 Dec; 154(4):281-8. doi: 10.5507/bp.2010.043.
Flow injection analysis vs. ultra high performance liquid chromatography coupled with tandem mass spectrometry for determination of imatinib in human plasma; Mičová K, Friedecký D, Faber E, Polýnková A, Adam T.; Clin Chim Acta. 2010 Dec 14; 411(23-24):1957-62. doi: 10.1016/j.cca.2010.08.014. Epub 2010 Aug 13.
Oligodendroglia from ADSL-deficient patient produce SAICAribotide and SAMP; Zídková L, Krijt J, Sládková J, Hlobilková A, Magner M, Zikánová M, Kmoch S, Friedecký D, Zeman J, Elleder M, Adam T.; Mol Genet Metab. 2010 Oct-Nov; 101(2-3):286-8. doi: 10.1016/j.ymgme.2010.06.014. Epub 2010 Jun 25.
Imatinib dose escalation in two patients with chronic myeloid leukemia, with low trough imatinib plasma levels measured at various intervals from the beginning of therapy and with suboptimal treatment response, leads to the achievement of higher plasma levels and major molecular response; Faber E, Friedecký D, Micová K, Divoká M, Katrincsáková B, Rozmanová S, Jarosová M, Indrák K, Adam T.; Int J Hematol. 2010 Jun; 91(5):897-902. doi: 10.1007/s12185-010-0576-y. Epub 2010 May 1.
Capillary electrophoresis determination of thiopurine methyl transferase activity in erythrocytes; Tomkova J, Friedecky D, Polynkova A, Adam T.; J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jul 1; 877(20-21):1943-5. doi: 10.1016/j.jchromb.2009.05.005. Epub 2009 May 13.
ITPase activity in dry blood spots is comparable with that in fresh erythrocytes; Tomkova J, Friedecky D, Vyskocilova P, Adam T.; Nucleosides Nucleotides Nucleic Acids. 2008 Jun; 27(6):656-60. doi: 10.1080/15257770802143897.
Determination of ITPase activity by capillary electrophoresis; Friedecky D, Tomkova J, Adam T.; Clin Chem. 2007 Jun; 53(6):1164-5. doi: 10.1373/clinchem.2007.086058.
Capillary electrophoretic method for nucleotide analysis in cells: application on inherited metabolic disorders; Friedecký D, Tomková J, Maier V, Janost’áková A, Procházka M, Adam T.; Electrophoresis. 2007 Feb; 28(3):373-80. doi: 10.1002/elps.200600262.
Synthesis and mass spectrometric fragmentation characteristics of imidazole ribosides-analogs of intermediates of purine de novo synthetic pathway; Vyskocilová P, Hornik P, Friedecký D, Frycák P, Lemr K, Adam T.; Nucleosides Nucleotides Nucleic Acids. 2006; 25(9-11):1237-40. doi: 10.1080/15257770600894691.
Analysis of intracellular nucleotides by capillary electrophoresis-mass spectrometry; Friedecký D, Bednár P, Procházka M, Adam T.; Nucleosides Nucleotides Nucleic Acids. 2006; 25(9-11):1233-6. doi: 10.1080/15257770600894667.
Analysis of aminoimidazole ribosides by capillary electrophoresis–diagnosing defects in second part of purine biosynthetic pathway; Hornik P, Vyskocilová P, Friedecký D, Janostáková A, Adamová K, Adam T.; Clin Chim Acta. 2007 Feb; 376(1-2):184-9. doi: 10.1016/j.cca.2006.08.020. Epub 2006 Sep 29.
Diagnosing AICA-ribosiduria by capillary electrophoresis; Hornik P, Vyskocilová P, Friedecký D, Adam T.; J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Oct 20; 843(1):15-9. doi: 10.1016/j.jchromb.2006.05.020. Epub 2006 Jun 23.
Analytical derivatization-a tool for determination of orotic acid; Husková R, Barták P, Cáp L, Friedecký D, Adam T.; J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Jan 25; 799(2):303-9. doi: 10.1016/j.jchromb.2003.10.068.
High-throughput capillary electrophoretic method for determination of total aminothiols in plasma and urine; Lochman P, Adam T, Friedecký D, Hlídková E, Skopková Z.; Electrophoresis. 2003 Apr; 24(7-8):1200-7. doi: 10.1002/elps.200390154.
Screening method for inherited disorders of purine and pyrimidine metabolism by capillary electrophoresis with reversed electroosmotic flow; Adam T, Lochman P, Friedecký D.; J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Feb 15; 767(2):333-40. doi: 10.1016/s1570-0232(01)00591-8.
Capillary electrophoresis for detection of inherited disorders of purine and pyrimidine metabolism: a selective approach; Friedecký D, Adam T, Barták P.; Electrophoresis. 2002 Feb; 23(4):565-71. doi: 10.1002/1522-2683(200202)23:4<565::AID-ELPS565>3.0.CO; 2-S.
Mass spectrometry for analysis of purine and pyrimidine compounds; Lemr K, Adam T, Frycák P, Friedecký D; Adv Exp Med Biol. 2000; 486:399-403. doi: 10.1007/0-306-46843-3_76.
Fast analysis of antibacterial isothiazolones by capillary electrophoresis; Barták P, Bednár P, Friedecký D, Haviger A, Sevcík J.; J Chromatogr B Biomed Sci Appl. 2001 Jul 15; 758(2):323-5. doi: 10.1016/s0378-4347(01)00198-0.
Capillary electrophoresis for detection of inherited disorders of purine and pyrimidine metabolism; Adam T, Friedecký D, Fairbanks LD, Sevcík J, Barták P.; Clin Chem. 1999 Dec; 45(12):2086-93.